The　Sichuan–Tibet　Engineering　Corridor　(STEC),　which　provides　the　key　function　of　transportation　between　the　plain　and　plateau　regions,　is　subjected　to　widely　distributed　landslides　in　the　southeastern　margins　of　the　Tibetan　Plateau.　This　study　investigated　the　landslides　in　terms　of　geomorphological　and　geological　analyses　and　susceptibility　assessment　along　the　western　STEC　between　Changdu　and　Nyingchi　Cities,　which　is　characterized　by　extremely　complex　geoenvironments　across　three　major　river　catchments.　The　results　suggested　the　spatial　feature　that　the　landslides　preferentially　occurred　in　river　valley　regions　with　high　elevation　and　distinctive　local　relief.　Soft　rock　types　of　shale,　siltstone,　schist　and　gneiss　controlled　most　landslide　areas,　while　faults　and　rivers　strongly　dominated　landslide　formation.　Landslide　susceptibility　results　performed　by　the　support　vector　machine　(SVM),　k-nearest　neighbor　(KNN),　and　multilayer　perception　(MLP)　models　were　highly　dependent　on　various　sample　sets,　revealing　different　hazard-formation　backgrounds　among　the　Lancang,　Nu,　and　Yarlung　Tsangpo　(YLTP)　river　catchments.　A　comparative　analysis　demonstrated　the　most　robust　model,　the　SVM,　indicating　that　lithology,　elevation,　local　relief,　slope,　and　distance　to　faults　were　the　most　significant　factors　causing　landslides.　In　summary,　the　investigations　signified　that　the　development　of　landslides　along　the　STEC　was　macroscopically　controlled　by　regional　and　vertical　zonation　of　the　tectonic　geomorphology　driven　by　regional　uplift,　and　was　locally　dominated　by　lithology　and　suture　zones.　Eventually,　further　surface　erosion　and　earthquakes　dynamically　offered　inducements　for　landslide　initiation.　This　study　strengthens　the　understanding　of　landslide　development　and　susceptibility　in　response　to　landscape　evolution　in　southeastern　Tibet,　and　provides　a　conceptual　model　for　disaster　prevention　and　mitigation　in　similar　high-relief　plateau　margin　regions.　©　2023