Massive　commodity　transactions　lead　to　enormous　virtual　water　and　water　pollution　transfer;　this　phenomenon　will　be　intensified　within　the　process　of　Regional　Comprehensive　Economic　Partnership　(RCEP)　enforcement.　This　study　applied　multi-regional　input-output　and　scenario　simulation　approach　to　reveal　the　virtual　water　elements　flow,　while　exploring　the　trade　structure　optimisation　roadmap　for　China.　Results　unveiled　that　China　was　a　virtual　water　net　exporter　(9.17　billion　tons),　also　the　largest　importer　of　water　pollutants　(N　622456　tons　and　P　136110　tons)　among　RCEP　countries　in　2015.　In　order　to　alleviate　the　water　pressure　in　China,　the　textiles　and　other　manufacturing　industries　should　be　limited,　while　the　service　industry　is　encouraged.　Optimal　scenario　can　realize　29.8%　water　conservation　and　8%　water　pollutants　reduction　and　also　achieve　a　36.5　million　dollars　trade　volume　increase.　This　research　improves　trade-off　balance　between　water　environment　and　economy　at　multi-regional　level　and　accelerates　green　trade　in　economic　partnerships　globally.