We　first　report　a　pH-responsive　multifunctional　nano　pesticide-fertilizer　complex　based　on　zeolitic　imidazolate　framework-8　(ZIF-8)　and　RNA　interference　(RNAi)　technology　for　synergistic　control　of　wilt　disease　caused　by　Rhizoctonia　solani,　and　promotion　of　crop　growth.　Chemical　pesticide　prochloraz　(Pro),　biological　pesticide　small　interfering　RNA　(siRNA),　and　a　plant　growth　regulator　diethyl　aminoethyl　hexanoate　(DA-6)　were　loaded　in　Pro/DA-6　@ZIF-8　@siRNA　nanoparticles　(Nps).　The　Nps　had　a　rhombic　orthododecahedron　structure　and　a　hydrated　particle　size　of　841.7　±　12.8　nm.　SiRNA　has　good　stability　due　to　the　protection　of　the　nanocarrier　as　well　as　an　excellent　controlled-release　behavior　under　acidic　conditions　due　to　the　degradation　of　coordination　bonds.　The　Nps　can　be　adsorbed　and　transmitted　via　pathogenic　mycelium　to　enhance　the　efficacy　of　non-invasive　pesticides.　Compared　to　Pro　technical,　siRNA　and　Pro　co-delivered　by　ZIF-8　had　a　synergistic　inhibitory　effect　on　pathogenic　fungi.　Due　to　the　slow-release　of　DA-6　and　the　supply　of　trace　elements,　the　Nps　significantly　promoted　rice　seedling　growth　by　regulation　of　key　metabolic　enzymes,　and　the　nutritional　function　of　Nps　as　a　zinc　ion　fertilizer　was　demonstrated.　Biological　studies　further　verified　that　nano-carrier　had　good　biosafety　and　reduced　environmental　risks.　Therefore,　this　novel　nano　pesticide-fertilizer　complex　has　potential　applications　for　the　effective　management　of　plant　disease　to　enhance　environmental　safety.　©　2023　Elsevier　B.V.