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Author:

Li, Xiaoyi (Li, Xiaoyi.) | Qu, Wenyan (Qu, Wenyan.) | Yan, Jing (Yan, Jing.) | Tan, Jianjun (Tan, Jianjun.) (Scholars:谭建军)

Indexed by:

EI Scopus SCIE

Abstract:

Noncoding RNAs (ncRNAs) play crucial roles in many cellular life activities by interacting with proteins. Identification of ncRNA-protein interactions (ncRPIs) is key to understanding the function of ncRNAs. Although a number of computational methods for predicting ncRPIs have been developed, the problem of predicting ncRPIs remains challenging. It has always been the focus of ncRPIs research to select suitable feature extraction methods and develop a deep learning architecture with better recognition performance. In this work, we proposed an ensemble deep learning framework, RPI-EDLCN, based on a capsule network (CapsuleNet) to predict ncRPIs. In terms of feature input, we extracted the sequence features, secondary structure sequence features, motif information, and physicochemical properties of ncRNA/protein. The sequence and secondary structure sequence features of ncRNA/protein are encoded by the conjoint k-mer method and then input into an ensemble deep learning model based on CapsuleNet by combining the motif information and physicochemical properties. In this model, the encoding features are processed by convolution neural network (CNN), deep neural network (DNN), and stacked autoencoder (SAE). Then the advanced features obtained from the processing are input into the CapsuleNet for further feature learning. Compared with other state-of-the-art methods under 5-fold cross-validation, the performance of RPI-EDLCN is the best, and the accuracy of RPI-EDLCN on RPI1807, RPI2241, and NPInter v2.0 data sets was 93.8%, 88.2%, and 91.9%, respectively. The results of the independent test indicated that RPI-EDLCN can effectively predict potential ncRPIs in different organisms. In addition, RPI-EDLCN successfully predicted hub ncRNAs and proteins in Mus musculus ncRNA-protein networks. Overall, our model can be used as an effective tool to predict ncRPIs and provides some useful guidance for future biological studies.

Keyword:

Author Community:

  • [ 1 ] [Li, Xiaoyi]Beijing Univ Technol, Fac Environm & Life, Dept Biomed Engn, Beijing Int Sci & Technol Cooperat Base Intelligen, Beijing 100124, Peoples R China
  • [ 2 ] [Qu, Wenyan]Beijing Univ Technol, Fac Environm & Life, Dept Biomed Engn, Beijing Int Sci & Technol Cooperat Base Intelligen, Beijing 100124, Peoples R China
  • [ 3 ] [Yan, Jing]Beijing Univ Technol, Fac Environm & Life, Dept Biomed Engn, Beijing Int Sci & Technol Cooperat Base Intelligen, Beijing 100124, Peoples R China
  • [ 4 ] [Tan, Jianjun]Beijing Univ Technol, Fac Environm & Life, Dept Biomed Engn, Beijing Int Sci & Technol Cooperat Base Intelligen, Beijing 100124, Peoples R China

Reprint Author's Address:

  • 谭建军

    [Tan, Jianjun]Beijing Univ Technol, Fac Environm & Life, Dept Biomed Engn, Beijing Int Sci & Technol Cooperat Base Intelligen, Beijing 100124, Peoples R China

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Source :

JOURNAL OF CHEMICAL INFORMATION AND MODELING

ISSN: 1549-9596

Year: 2023

Issue: 7

Volume: 64

Page: 2221-2235

5 . 6 0 0

JCR@2022

ESI Discipline: CHEMISTRY;

ESI HC Threshold:20

Cited Count:

WoS CC Cited Count: 2

SCOPUS Cited Count: 3

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 10

Affiliated Colleges:

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