Among　the　single-atom　catalysts　(SACs),　the　bimetallic　single-atom　catalysts　play　an　increasingly　promising　role　in　the　oxidative　removal　of　volatile　organic　compounds　(VOCs)　due　to　their　high　efficiency.　However,　it　remains　a　significant　challenge　to　resist　SO2　poisoning　in　industrial　applications.　In　this　work,　we　report　(i)　the　synthesis　of　three-dimensionally　ordered　mesoporous　Fe2O3-supported　bimetallic　AuPt　single-atom　(denote　as　Au1Pt1/meso-Fe2O3)　catalyst　via　a　modified　polyvinyl　alcohol-protected　reduction　route;　(ii)　catalytic　performance　of　the　catalysts　for　methanol　oxidation;　and　(iii)　catalytic　and　SO2-resistant　mechanism.　It　was　found　that　compared　with　Pt1/meso-Fe2O3　and　Ptnp/meso-Fe2O3,　Au1Pt1/meso-Fe2O3　exhibited　better　catalytic　activity　for　methanol　combustion,　with　the　temperature　at　90%　methanol　conversion,　TOFnoble　metal　at　120　°C,　and　apparent　activation　energy　being　137　°C　at　a　space　velocity　of　20　000　mL　g–1　h–1,　6.51　×　10–2　s–1,　and　36　kJ　mol−　1,　respectively.　The　enhanced　activity　was　associated　with　the　improved　reducibility,　methanol　adsorption　ability,　and　strong　interaction　between　noble　metal　and　support.　The　reaction　pathway　was　deduced　to　follow　a　sequence　of　methanol　→　methoxy　species　→　formaldehyde　→　formic　acid　→　CO2　and　H2O.　Furthermore,　the　order　of　SO2　resistance　was　Au1Pt1/meso-Fe2O3　＞　Pt1/meso-Fe2O3　＞　Ptnp/meso-Fe2O3.　The　good　SO2　resistance　of　the　Au1Pt1/meso-Fe2O3　catalyst　was　attributed　to　the　Au−Pt　bimetallic　single　atoms　uniformly　dispersed　on　the　meso-Fe2O3　with　the　strong　ability　of　sulfate　decomposition　and　the　protection　of　the　active　sites　by　meso-Fe2O3　as　a　sacrificial　site.　This　work　presents　a　novel　way　for　developing　high-performance　catalysts　for　VOCs　elimination　in　the　presence　of　SO2.　©　2023　Elsevier　B.V.