This　paper　presents　a　novel　approach　for　the　fabrication　of　low　cost　Electrochemical-Surface　Enhanced　Raman　Scattering　(EC-SERS)　sensing　platforms.　Laser　Induced　Graphene　(LIG)　electrodes　were　readily　fabricated　by　direct　laser　writing　of　polyimide　tapes　and　functionalized　with　silver　nanoparticles　(Ag　NPs)　to　obtain　hybrid　Ag　NPs　-　LIG　electrodes　suitable　for　EC-SERS　analysis.　Detection　was　achieved　by　coupling　a　handheld　potentiostat　with　a　Raman　spectrograph,　enabling　measurement　of　SERS　spectra　of　target　analytes　generated　during　voltage　sweeps　in　the　0.0　to　-1.0　V　interval　range.　The　sensing　capabilities　of　the　fabricated　system　were　first　tested　with　model　molecule　4-aminobenzenethiol　(4-ABT).　Following　sensitive　detection　of　4-ABT,　EC-SERS　analysis　of　food　contaminant　melamine　in　milk　and　antibiotic　difloxacin　hydrochloride　(DIF)　in　river　water　was　demonstrated,　achieving　sensitive　detection　of　both　analytes　without　pre-treatment　steps.　The　easiness　of　fabrication,　versatility　of　design,　rapid　analysis　time　and　potential　miniaturization　of　the　system　make　Ag　NPs　-　LIG　electrodes　suitable　for　a　large　range　of　in　situ　applications　in　the　field　of　food　monitoring　and　for　environmental　analysis.