Tolueneis　the　most　common　volatile　organic　compound　(VOC),　andthe　MnO2-based　catalyst　is　one　of　the　excellent　nonpreciousmetal　catalysts　for　toluene　oxidation.　In　this　study,　the　effectsof　MnO2　precursors　and　the　support　types　on　the　oxidationperformance　of　toluene　were　systematically　explored.　The　results　showedthat　the　15MnO(2)/MS-CeO2-N　catalyst　with　Mn(NO3)(2)center　dot　4H(2)O　as　the　precursor　and　themesoporous　CeO2　nanosphere　(MS-CeO2)　as　thesupport　exhibited　the　most　excellent　performance.　To　reveal　the　reasonbehind　this　phenomenon,　the　calcination　process　of　the　catalyst　precursorand　the　reaction　process　of　toluene　oxidation　were　investigated　by　in　situ　DRIFTS.　It　was　found　that　the　MnO2　precursorand　the　type　of　catalyst　support　could　have　a　large　effect　on　thereaction　pathway　and　the　produced　intermediates.　Therefore,　the　rolesof　the　MnO2　precursor　and　the　type　of　support　should　bekey　considerations　when　developing　the　high-performance　MnO2-based　toluene　oxidation　catalyst.　Themesoporous　CeO2　nanosphere　with　excellentstructural　properties　was　facilely　synthesized　and　utilized　as　thesupport　of　the　MnO2/CeO2　catalyst　for　oxidationof　toluene.　The　effects　of　MnO2　precursors　and　supporttype　on　the　performances　of　toluene　oxidation　were　investigated.　Thereaction　intermediates　and　the　pathway　of　the　toluene　oxidation　reactionwere　studied　by　the　in　situ　DRIFTS　technique.