Four　seismic　isolation　specimens　were　designed,　fabricated,　and　subjected　to　physical　loading　tests　to　enhance　the　seismic　performance　of　a　high-pier　continuous　rigid-frame　bridge.　A　finite　element　model　of　the　seismic　isolation　structure　of　the　high-pier　was　established　using　numerical　simulation　software.　The　entire　bridge　model　was　established　based　on　the　multi-scale　modeling　method　to　investigate　the　seismic　response　of　the　high-pier　continuous　rigid　frame　bridge　under　different　seismic　waves.　The　results　indicate　that　the　seismic　isolation　pier　has　self-centering　and　energy　dissipation　capabilities.　The　seismic　isolation　pier　has　satisfactory　energy　dissipation　capacity　and　ductility　when　the　ratio　of　the　long-axis　and　short-axis　radii　is　1.5.　The　results　of　the　finite-element　simulation　corresponded　well　with　the　experimental　results.　Significant　damage　occurred　to　the　concrete　at　the　bottom　and　corner　of　the　pier,　and　the　reinforcement　did　not　reach　its　yield　strength　throughout　the　loading　process.　Therefore,　measures　must　be　implemented　to　ensure　the　seismic　performance　of　the　structure.　The　pier　bottom　self-centering　seismic　isolation　structure　effectively　absorbs　shocks,　as　evidenced　by　reduced　absolute　acceleration　and　relative　displacement　at　the　pier　top,　decreased　shear　force　and　bending　moment　at　the　pier　bottom,　and　minimized　girder　displacement.　It　was　recommended　that　the　ratio　of　the　long-axis　and　short-axis　radii　be　adopted　as　1.5–2.0　and　that　the　pier　height　be　selected　as　60　m–100　m.　These　results　provide　a　reference　for　the　research　and　applications　of　this　type　of　structure.　©　2023