Cellulose　immobilized　palladium　(0)　nanoparticles　(PdNPs)　were　prepared　for　the　use　in　scalable　catalytic　reactions　in　flow.　Preparation　of　the　catalyst　is　remarkably　simple　and　fast,　where　a　palladium　acetate　solution　is　drop-casted　onto　cellulose　paper　and　then　exposed　to　1　atm　of　hydrogen　for　a　mere　90　s　to　produce　embedded　Pd(0)　nanoparticles.　This　catalyst　system　is　efficient　in　the　hydrogenation　of　alkenes,　nitroarenes,　ketones,　and　enamides,　with　products　formed　in　high　yields,　under　ambient　pressure　and　temperature.　The　system　is　also　effective　for　transfer　hydrogenation　using　ammonium　formate　as　an　alternative　hydrogen　source.　A　high　catalyst　stability　and　reusability　are　demonstrated　along　with　the　chemoselective　and　scalable　synthesis　of　industrially　important　fine　chemicals,　including　the　biobased　molecule　cyrene.　Copyright　©　2018　American　Chemical　Society.