Objective　To　investigate　the　effect　of　stenosis　characteristics　(vascular　elasticity　and　plaque　properties)　on　myocardial　ischemia.　Methods　An　ideal　geometric　multi⁃scale　coronary　stenosis　model　based　on　fluid⁃structure　interaction　was　established,　and　the　fractional　flow　reserve　(FFR)　was　simulated　to　evaluate　myocardial　ischemia.　The　effects　of　vascular　elastic　wall　(elastic　modulus　of　1　MPa)　and　rigid　wall,　plaque　types　(lipid⁃rich　plaque　and　calcified　plaque)　and　plaque　volume　on　myocardial　ischemia　were　considered　separately.　Results　The　FFRCT　simulation　result　of　vessels　with　elastic　wall　was　larger　than　that　with　rigid　wall　under　all　stenosis　situations.　The　FFRCT　of　vessels　in　lipid⁃rich　lesions　was　higher　than　that　of　calcified　plaque　(P=　0.　001).　The　trapezoidal　plaque　volume　was　larger　than　the　cosine　plaque　volume,　and　the　FFRCT　of　vessels　in　trapezoidal　plaque　was　smaller　than　that　of　cosine　plaque　(P=　0.　001).　Conclusions　Vascular　elasticity　is　a　critical　factor　to　simulate　vascular　hemodynamics.　In　moderate　stenosis,　calcified　plaques　are　more　likely　to　induce　myocardial　ischemia　due　to　the　larger　luminal　deformation　and　dilation　of　rich　lipid　plaque.　When　the　stenosis　is　constant,　the　smaller　the　plaque　volume,　the　higher　the　FFRCT　and　the　smaller　the　possibility　of　myocardial　ischemia.　©　2023　Shanghai　Jiaotong　University　School　of　Medicine.　All　rights　reserved.