Metallic　materials　have　been　widely　used　owing　to　their　good　mechanical　property　and　high　flexibility.　However,　there　are　certain　limitations　for　practical　applications　such　as　low　anti-bacterial,　cell　adhesion,　surface　wettability　and　corrosion　resistance　property.　In　this　paper,　laser　microprocessing　of　titanium　(Ti)　alloy　and　magnesium　(Mg)　alloy　has　been　conducted,　respectively.　The　cell　adhesion　of　Ti6Al4V　alloy　and　Mg-Gd-Ca　alloy　after　laser　microprocessing　has　been　investigated.　The　results　show　that　MC3T3-E1　cells　have　been　successfully　adhered　to　the　treated　surface　and　optical　density　are　significantly　increased　due　to　hybrid　micro/nano　structure.　Anti-bacterial　test　shows　that　the　anti-bacterial　rates　against　E.　coli　of　laser-treated　surface　was　up　to　72%.　Meanwhile,　water　contact　angle　has　been　increased　from　57.4°　to　135.3°　indicating　the　changing　of　surface　wettability　from　hydrophilic　to　hydrophobic.　Moreover,　corrosion　test　of　Mg-Gd-Ca　alloy　has　been　conducted,　which　has　been　significantly　improved　after　laser　microprocessing.　The　present　work　showed　that　laser　surface　microprocessing　could　be　a　promising　technique　for　fabricating　different　biomedical　property　surfaces.　Copyright　©　2021　by　ASME