In　this　paper,　A　high　sensitivity　sensor　chip　based　on　VCSELs　and　localized　surface　plasmon　resonance　of　gold　nanoparticle　array　is　demonstrated.　The　anodic　aluminum　oxide　film　is　used　as　a　mask　to　fabricate　the　hexagonal　arrays　of　Au　nanoparticles　by　magnetron　sputtering　and　lift-off　process　on　the　VCSELs＇　end　surface.　Different　concentrations　of　sucrose　solution　with　the　refractive　index　between　1.333　and　1.3998　are　detected　by　the　LSPR　sensor　which　is　constituted　by　VCSELs　(light　source),　gold　nanoparticle　arrays　(sensing　layer)　and　microfluidic.　The　light　intensity　is　varied　by　the　change　of　the　background　refractive　index.　The　experimental　result　shows　that　the　optical　output　power　of　the　biosensor　depends　on　the　refractive　index　in　a　nearly　linear　way.　The　maximum　sensitivity　is　1.1×105nW/RIU　which　is　higher　than　that　of　biosensor　based　on　the　shift　for　resonance　wavelength.　©　2021　IEEE.