Mixed-valance　manganites　with　strong　electron　correlation　exhibit　strong　potential　for　spintronics,where　emergent　magnetic　behaviors,such　as　propagation　of　high-frequency　spin　waves　and　giant　topological　Hall　Effects　can　be　driven　by　their　mesoscale　spin　textures.Here,we　create　magnetic　vortex　clusters　with　flux　closure　spin　configurations　in　single-crystal　La0.67Sr0.33MnO3　wire.A　distinctive　transformation　from　out-of-plane　domains　to　a　vortex　state　is　directly　visualized　using　magnetic　force　microscopy　at　4　K　in　wires　when　the　width　is　below　1.0　μm.The　phase-field　modeling　indicates　that　the　inhomogeneous　strain,accompanying　with　shape　anisotropy,plays　a　key　role　for　stabilizing　the　flux-closure　spin　structure.This　work　offers　a　new　perspective　for　understanding　and　manipulating　the　non-trivial　spin　textures　in　strongly　correlated　systems.