A　nanoscale　confined　fluid　structure　with　nanopatterned　surface　has　been　investigated　by　using　nonequilibrium　molecular　dynamics　simulations　and　kinetic　theory.　The　negative　differential　thermal　resistance　(NDTR)　effect　has　been　observed　in　such　a　nanoscale　solid-fluid-solid　sandwiched　structure,　but　for　high　fluid　density,　the　NDTR　effect　is　weak　or　even　disappears.　In　the　present　paper,　it　is　shown　that　the　NDTR　effect　can　be　enhanced　or　reproduced　in　the　range　of　Delta　T　＞　150　K　roughly　by　introducing　a　nanopatterned　structure　to　the　cold　surface　owing　to　the　enhanced　molecule　adsorption　in　the　nanocavities.　The　findings　in　the　present　paper　pave　the　way　for　the　application　of　NDTR　in　the　design　of　a　thermal　device.