In　order　to　analyze　the　significant　influence　of　lateral　inhomogeneity　of　site　on　horizontal-to-vertical　spectral　ratio　(HVSR)　curves,　the　diffuse　field　approach　proposed　by　Sánchez-Sesmaet　alwas　adopted　to　simulate　the　HVSR　curves　of　2-D　sediment　topography　by　calculating　the　imaginary　part　of　Green＇s　functions　of　total　wave　field.　The　imaginary　part　of　Green＇s　functions　was　solved　by　the　dynamic　stiffness　matrix　and　in-plane　inclined　Green＇s　functions　based　on　the　indirect　boundary　element　method　(IBEM).　The　HVSR　curves　of　2-D　sediment　topographies　and　corresponding　1-D　layered　half-space　were　compared,　the　influences　of　sediment　topography　shapes　and　the　relative　position　of　calculation　points　on　the　HVSR　curve　were　discussed　in　detail.　The　results　show　that　the　effect　of　impedance　ratio　between　inside　and　outside　materials　of　sediment　topography　on　HVSR　is　the　most　significant;　With　the　increase　of　the　impedance　ratio　and　the　slopes　of　the　interface　on　the　sediment　side,　the　frequencies　of　the　first　peak　of　HVSR　curves　increase　significantly,　which　can　be　up　to　3.3　times　of　the　corresponding　layered　half-space　results,　simultaneously,　platform　emerges　on　HVSR　curves;　Amplitudes　of　HVSR　curves　in　high　frequency　band　increase　with　the　decrease　of　distances　from　the　calculation　points　to　the　sediment　boundary.　According　to　the　results　obtained　in　this　study,　the　HVSR　method　can　be　used　to　preliminarily　determine　the　place　where　local　sediment　topography　exists.　From　this　aspect,　the　cost　of　regional　geophysical　investigation　can　be　reduced　visibly　via　HVSR　method.　Copyright　©2021　ACTA　SEISMOLOGICA　SINICA.　All　rights　reserved.