The　Guangdong–Hong　Kong–Macau　(GBA)　metropolitan　of　China　is　pioneering　in　realizing　environment-friendly　development.　However,　health　and　economic　burden　attributed　to　air　pollution　under　different　climate　and　end-of-pipe　control　scenarios　has　not　been　evaluated.　This　study　applies　the　IMED|CGE,　WRF-Chem　and　IMED|HEL　models　assess　PM2.5-　and　O3-associated　health　and　economic　consequences.　Results　demonstrate　that　PM2.5　concentration　in　2050　will　drop　by　12.9%　and　56.4%　under　1.5　°C　target　and　end-of-pipe　technology,　respectively,　contributing　to　7.7%　and　35.6%　decreases　in　mortality　and　67.3%　and　97.9%　reductions　in　morbidity.　The　O3　concentration　will　decrease　by　8.3%　and　13.3%,　respectively,　contributing　to　10.4%　and　15.2%　drops　in　mortality　and　10.8%　and　15.8%　declines　in　morbidity.　Besides,　the　health　loss　saved　by　alleviating　PM2.5　and　O3　pollution　using　end-of-pipe　technologies　is　remarkable,　amounting　to　31.0　and　9.3　billion　USD　in　2050,　respectively.　It　suggests　that　O3　pollution　in　GBA　is　difficult　to　be　addressed　and　higher　levels　of　end-of-pipe　technology　progress　should　be　deployed　to　obtain　significant　co-benefits.　©　2023