In　some　important　chemical　processes,　selective　removal　of　C2H2　from　other　gases　is　necessary.　The　method　of　selecting　porous　materials　for　separation　is　energy-efficient　and　economical　in　comparison　with　some　traditional　methods,　such　as　solvent　extraction　and　low-temperature　distillation.　Herein,　we　present　three　nanoporous　Cu(II)-adenine-based　metal-organic　frameworks　(MOFs),　[Cu(AD)(AC)],　[Cu-2(AD)(2)(SA)],　and　[Cu-2(AD)(2)(GA)],　denoted　as　Cu-AD-AC,　Cu-AD-SA,　and　Cu-AD-GA,　respectively　(HAD　=　adenine,　HAC　=　acetic　acid,　H(2)SA　=　succinic　acid,　and　H(2)GA　=　glutaric　acid).　The　adenine　ligands　and　secondary　aliphatic　acid　ligands　of　these　MOFs　are　easy-accessible.　The　MOFs　show　isomorphic　three-dimensional　(3D)　microporous　framework　structures　with　slightly　different　pore　microenvironments　due　to　the　presence　of　different　aliphatic　acid　ligands.　There　are　1D　channels　of　similar　to　4.5　to　similar　to　5　&　Aring;　diameter　in　the　MOFs,　the　surfaces　of　which　are　decorated　with　a　Lewis　basic　site.　The　subtle　structural　differences　lead　to　large　differences　in　the　stability　and　porosity　of　the　MOFs.　Among　them,　Cu-AD-SA　showed　a　relatively　high　adsorption　capacity　of　C2H2.　In　addition,　adsorption　isotherm　measurements　for　single-component　gases　and　breakthrough　experiments　for　binary　gas　mixtures　suggested　that　Cu-AD-SA　could　selectively　adsorb　C2H2　from　a　C2H2/C2H4　or　a　C2H2/CO2　mixture.