The　oxime-urethane　group　can　undergo　dynamic　reversible　reaction　at　room　temperature,　which　can　endow　polyurethane　(PU)　with　self-healing　ability　at　ambient　temperatures.　This　study　prepared　CO2-based　PU　containing　oxime-urethane　groups　and　introduced　it　into　asphalt　to　enhance　the　self-healing　performance　of　asphalt　at　room　temperature.　Firstly,　the　chemical　structure,　self-healing　performance,　and　thermal　stability　of　the　prepared　PU　and　ordinary　PU　were　characterized.　Then,　the　two　types　of　PU　were　sheared　in　asphalt　to　prepare　PU　modified　asphalts,　the　chemical　characteristics　and　microstructure　of　the　modified　asphalts　were　characterized.　Finally,　the　healing　performance　of　different　asphalts　at　room　temperature　was　characterized.　The　results　indicated　that　the　prepared　self-healing　PU　had　good　thermal　stability　and　exhibited　rapid　self-healing　performance　at　room　temperature.　After　6　h　of　healing,　the　maximum　tensile　strength　can　recover　to　88.78%　of　its　initial　value.　Self-healing　(S-PU)　was　successfully　introduced　into　asphalt　system　without　decomposition,　but　due　to　the　role　of　intermolecular　hydrogen　bond　and　dynamic　covalent　bond　of　PU,　its　dispersion　in　asphalt　was　poor.　The　addition　of　S-PU　can　significantly　enhance　the　self-healing　capability　of　asphalt　at　room　temperature.　This　study　provides　a　new　idea　for　the　preparation　of　green　PU　modified　asphalt　containing　dynamic　covalent　bond.　©　2024　Elsevier　Ltd