To　investigate　the　potential　impact　of　emission　reduction　measures　on　ozone　(O3　)　formation　under　the　carbon　neutrality　target,　we　examined　the　changes　in　O3　concentration　and　their　sensitivity　to　various　parameters　in　the　urban　and　suburban　areas　of　the　Guangdong-Hong　Kong-Macao　Greater　Bay　Area　(GBA).　In　this　study,　we　used　the　Weather　Research　and　Forecasting　(WRF),　the　Sparse　Matrix　Operator　Kernel　Emissions　(SMOKE)　and　the　Community　Multi-scale　Air　Quality　Modeling　system　(CMAQ)　air　quality　model　to　simulate　O3　formation　in　three　key　years　of　2020,　2030　and　2060,　based　on　the　Ambitious-pollution-Neutral-goal　scenario　data　from　the　Dynamic　Projection　for　Emissions　in　China　(DPEC)　model.　The　decoupled　direct　method　(DDM)　module　embedded　in　CMAQ　was　used　to　calculate　the　first-order　sensitivity　coefficients　of　O3　to　nitrogen　oxides　(SO3_NOx)　and　volatile　organic　compounds　(SO3_VOC).　The　results　show　several　important　trends　in　the　O3　concentrations　and　sensitivity.　(1)　For　the　changes　in　O3　concentrations,　in　terms　of　different　seasons,　the　O3　concentration　in　the　GBA　region　shows　an　increasing　trend　in　winter　in　both　2030　and　2060　compared　to　2020.　In　terms　of　different　cities,　the　O3　concentration　in　Shenzhen　shows　a　significant　increasing　trend　compared　to　the　other　cities.　(2)　For　changes　in　O3　sensitivity,　SO3_NOx　shows　an　increasing　trend,　with　the　negative　area　declining　and　the　positive　area　increasing.　In　2030,　the　negative　absolute　value　of　SO3_NOx　is　reduced,　indicating　that　the　NOx　titration　effect　will　be　weakened.　In　2060,　SO3_NOx　becomes　positive　in　most　areas　of　the　GBA　region.　For　SO3_VOC,　the　future　scenario　shows　positive　values　throughout　the　study　area　for　all　years,　but　a　decreasing　trend.　©　2024,　Editorial　office　of　Journal　of　Resources　and　Ecology.　All　rights　reserved.