In　order　to　study　the　influence　of　prestressed　conditions　of　concrete　structure　on　the　seismic　response　of　the　nuclear　containment　structure　under　ultimate　safety　ground　motion,　in　this　paper,　only　three　prestressed　conditions,　which　are　instantaneous　prestress　loss,　long-term　prestress　loss　and　uniform　distribution　of　prestress　after　duct　grouting,　and　the　no　prestressed　condition　are　considered,　and　then　the　nonlinear　time　history　analysis　of　the　seismic　response　of　the　nuclear　containment　structure　is　conducted　by　establishing　their　refined　finite　element　models.　The　simulation　results　show　that　for　the　no　prestressed　condition,　the　containment　structure　has　a　large　number　of　cracks　running　through　the　thickness　of　the　section　in　the　weak　seismic　position　under　ultimate　safety　ground　motion,　and　the　structure　basically　enters　the　state　of　functional　failure;　while　the　whole　containment　structure　is　in　an　elastic　state　under　the　three　prestressed　conditions.　However,　cracks　occur　in　the　main　opening　areas　of　the　containment,　and　a　certain　number　of　tension　cracks　are　generated　at　the　bottom　of　the　containment　body　under　the　condition　of　uniform　prestress　distribution.　The　research　shows　that　the　prestressed　concrete　structure　can　significantly　improve　the　seismic　capacity　of　the　nuclear　containment　structure,　but　it　should　be　paid　attention　to　the　adverse　impact　of　the　uniform　prestress　distribution　that　may　occur　after　the　duct　grouting　on　the　seismic　safety　performance　of　the　nuclear　containment　structure　in　design.　The　research　results　can　provide　guidance　for　the　rational　use　of　the　seismic　advantages　of　prestressed　concrete　in　the　design　of　nuclear　containment　structure.　©　2023　Atomic　Energy　Press.　All　rights　reserved.