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Author:

Jiang, Zongli (Jiang, Zongli.) | Ren, Hongwei (Ren, Hongwei.) | Yang, Ziwei (Yang, Ziwei.) | Zhang, Jinli (Zhang, Jinli.) | Chen, Zheng (Chen, Zheng.)

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Abstract:

Comprehensive analysis of multi-omics data has now garnered significant attention. However, due to the diversity of multi-omics data, integrating multi-omics information presents a formidable challenge for researchers. Moreover, the high dimensionality and sparsity characteristics in omics data further complicate multi-omics data analysis. To address these challenges and obtain high-quality representations suitable for downstream tasks, we propose a self-supervised clustering learning framework called the Multi-view Feature Hierarchical Contrastive Clustering model (MFHCC) to extract multi-level features. Firstly, the proposed model considers multi-omics as multi-modality and employs an autoencoder for each modality to integrate diverse omics information simultaneously. Secondly, it utilizes a multilevel feature extraction framework with contrastive learning methods to mitigate the impact of redundant information and null values on representation quality while capturing semantic information embedded in the data. Additionally, the model incorporates a deep clustering module to guide the representation toward downstream tasks while integrating high-level features for guidance. Through extensive experiments conducted on pan-cancer datasets, we validate the effectiveness of MFHCC. For instance, the model achieves an accuracy exceeding 76% by omics types, thus confirming its superior performance. © 2023 IEEE.

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Author Community:

  • [ 1 ] [Jiang, Zongli]Beijing University of Technology, Beijing, China
  • [ 2 ] [Ren, Hongwei]Beijing University of Technology, Beijing, China
  • [ 3 ] [Yang, Ziwei]Kyoto University, Bioinformatics Center, Institute for Chemical Research, Kyoto, Japan
  • [ 4 ] [Zhang, Jinli]Beijing University of Technology, Beijing, China
  • [ 5 ] [Chen, Zheng]Sanken, Osaka University, Osaka, Japan

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Year: 2023

Page: 1182-1187

Language: English

Cited Count:

WoS CC Cited Count: 0

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ESI Highly Cited Papers on the List: 0 Unfold All

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Chinese Cited Count:

30 Days PV: 2

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