Applying　anaerobic　ammonium　oxidation　(anammox)　in　municipal　wastewater　treatment　plants　(MWWTPs)　can　unlock　significant　energy　and　resource　savings.　However,　its　practical　implementation　encounters　significant　challenges,　particularly　due　to　its　limited　compatibility　with　carbon　and　phosphorus　removal　processes.　This　study　established　a　pilot-scale　plant　featuring　a　modified　anaerobic-anoxic-oxic　(A2O)　process　and　operated　continuously　for　385　days,　treating　municipal　wastewater　of　50　m3/d.　For　the　first　time,　we　propose　a　novel　concept　of　partial　denitrifying　phosphorus　removal　coupling　with　anammox　(PDPRA),　leveraging　denitrifying　phosphorus-accumulating　organisms　(DPAOs)　as　NO2−　suppliers　for　anammox.　15N　stable　isotope　tracing　revealed　that　the　PDPRA　enabled　an　anammox　reaction　rate　of　6.14　±　0.18　μmol-N/(L·h),　contributing　57.4　%　to　total　inorganic　nitrogen　(TIN)　removal.　Metagenomic　sequencing　and　16S　rRNA　amplicon　sequencing　unveiled　the　co-existence　and　co-prosperity　of　anammox　bacteria　and　DPAOs,　with　Candidatus　Brocadia　being　highly　enriched　in　the　anoxic　biofilms　at　a　relative　abundance　of　2.46　±　0.52　%.　Finally,　the　PDPRA　facilitated　the　synergistic　conversion　and　removal　of　carbon,　nitrogen,　and　phosphorus　nutrients,　achieving　remarkable　removal　efficiencies　of　chemical　oxygen　demand　(COD,　83.5　±　5.3　%),　NH4+　(99.8　±　0.7　%),　TIN　(77.1　±　3.6　%),　and　PO43−　(99.3　±　1.6　%),　even　under　challenging　operational　conditions　such　as　low　temperature　of　11.7　°C.　The　PDPRA　offers　a　promising　solution　for　reconciling　the　mainstream　anammox　and　the　carbon　and　phosphorus　removal,　shedding　fresh　light　on　the　paradigm　shift　of　MWWTPs　in　the　near　future.　©　2024　Elsevier　Ltd