Utilization　of　CO2　into　value-added　products　is　one　of　the　important　ways　to　achieve　carbon　neutrality.　Metal-organic　frameworks　(MOF)　have　been　proven　to　be　promising　and　effective　materials,　relying　on　the　characteristic　of　porosity,　functional　adjustability,　abundant　active　sites　and　high　specific　surface　area.　Single-atom　catalysts　(SAC)　have　emerged　as　a　new　frontier　due　to　well-defined　structures　and　maximum　atom　utilization　efficiency　(100%).　By　combining　the　merits　of　both,　MOF-based　SAC　exhibits　enormous　potential　in　photocatalytic　/　electrocatalytic　CO2　reduction　reactions.　The　review　systematically　summarized　the　latest　research　progress　of　MOF-based　SAC　in　photocatalytic　/　electrocatalytic　CO2　reduction.　The　diverse　fabrication　strategies　and　principles　of　MOF-based　SAC,　including　MOF-immobilized　SAC　and　MOF-derived　SAC,　as　well　as　unique　advantages　demonstrated　in　photocatalytic　/　electrocatalytic　CO2　reduction,　were　discussed.　Finally,　a　perspective　on　MOF-photocatalysts　/　electrocatalysts　for　CO2　reduction　was　given.　©　2024　Beijing　University　of　Technology.　All　rights　reserved.