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Abstract:
Cherenkov-Excited Luminescence Scanned Tomography (CELST) involves a system of coupled continuous wave-domain diffusion equations for modeling. The excitation field quantized by the Complex Cosine (CC) method effectively simulates the forward light process in these equations. However, when considering x-ray-induced Cherenkov light within biological tissue, the CC-based excitation field lacks precision, instead requires the use of stochastic Monte Carlo (MC) methods. To accurately describe the radiation-induced light transport in biological tissue and CELST image reconstruction, in this paper, we develop a MC-based method for CELST, named sheet Monte Carlo (sMC). Experiments show that the sMC field can achieve 11.47 on contrast-to-noise ratio (CNR) and 0.74 on Pearson correlation (PC), while 7.25 and 0.57 for the CC initialization field under 4% noise level. Furthermore, our results highlight that the proposed excitation field exhibits superior reconstruction performance, especially when dealing with low ratios of fluorescent targets.
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MOLECULAR-GUIDED SURGERY:MOLECULES, DEVICES, AND APPLICATIONS X
ISSN: 1605-7422
Year: 2024
Volume: 12825
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SCOPUS Cited Count:
ESI Highly Cited Papers on the List: 0 Unfold All
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Chinese Cited Count:
30 Days PV: 8
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