The　highly　adjustable　properties　of　high-entropy　alloys　(HEAs)　offer　great　potential　for　developing　superior　materials　for　critical　structural　applications　in　high-temperature　conditions.　In　this　study,　Ni-Fe-Cr-Al-V　HEA　was　manufactured　by　laser　powder　bed　fusion,　which　has　a　unique　microstructure　composed　of　dislocation　substructure　and　Face-centered　cubic　+　L12　coherent　structure　and　achieves　the　desired　strength-ductility　combination.　Hot　isostatic　pressing　post-treatment　was　applied　on　the　laser　powder　bed　fusion-processed　HEA　to　further　improve　the　relative　density　and　optimize　the　mechanical　properties.　During　the　hot　isostatic　pressing　process,　the　precipitation　of　L12　and　B2　phases　can　be　ascribed　to　the　precipitation　modes　dominated　by　continuous　precipitation　and　discontinuous　precipitation,　respectively.　With　the　tensile　deformation　temperature　increasing　from　773-1,173　K,　the　softening　degree　of　HEA　increases　continuously,　and　the　dominant　deformation　mechanism　evolves　from　intragranular　dislocation　slip　to　grain　boundary　sliding.　At　temperatures　below　773　K,　precipitation　strengthening　significantly　improves　tensile　strength　and　ductility.　At　1,173　K,　the　grain　boundary　strength　decreases　and　grain　boundary　area　increases,　which　promotes　grain　boundary　sliding　and　contributes　to　plastic　deformation,　resulting　in　significant　softening.　©　The　Author(s)　2024.