To　study　the　rationality　and　disaster　prevention　resilience　of　the　spatial　layout　of　urban　epidemic　prevention　medical　rescue　system,　a　network　model　of　a　city蒺s　medical　epidemic　prevention　and　rescue　was　constructed　by　using　complex　network　technology,　analyzing　its　network　topology　and　basic　parameters　of　network　characteristics,　and　studying　the　invulnerability　of　structures　with　edge　and　point　connectivity　as　metrics　under　different　attack　models․　By　setting　different　network　redundancy　and　network　loads,　the　robustness　of　the　network　against　deterministic　attacks　and　random　attacks　were　studied․　The　research　result　can　provide　theoretical　support　for　the　spatial　optimization　layout　of　urban　epidemic　prevention　medical　rescue　system　and　the　strengthening　construction　of　core　sites․　©　2024　Beijing　University　of　Technology.　All　rights　reserved.