The　durability　of　asphalt　pavement　in　coastal　regions　has　been　a　widely　discussed　topic　due　to　the　coupling　effect　of　complex　climate　environment　and　seawater　erosion.　Aging-resistant　materials　(ARMs)　significantly　enhance　the　environment　resistance　of　high-viscosity　modified　asphalt　(HiMA),　but　their　impact　on　the　asphalt-aggregate　interface　interaction　and　seawater　erosion-induced　failure　remains　unclear.　In　this　study,　molecular　dynamics　simulation　was　employed　to　investigate　the　molecular-atomic　scale　interactions　at　the　HiMA-aggregate　interface　and　the　evolution　mechanism　of　seawater　erosion　with　different　ARMs.　An　analysis　of　the　interface　adhesion　mechanism　in　different　aging-resistant　HiMAs　was　conducted　based　on　molecular　polarity,　component　distribution,　and　nanostructure　evolution.　The　seawater　erosion　mechanism　at　the　interface　and　the　impact　of　ARMs　were　further　investigated.　The　research　indicates　that　ARMs　interact　extensively　with　asphalt　components　and　polymers,　altering　the　molecular　spatial　arrangement　and　nanostructure　characteristics　of　HiMA　at　the　aggregate　interface.　ARMs　promote　the　free　volume　and　diffusion　ability　of　asphalt　molecules　and　accelerate　their　aggregation　at　the　aggregate　interface.　With　the　addition　of　ARMs,　highly　polar　asphaltene　and　resin　molecules　intensify　their　movement　toward　the　aggregate　interface,　exhibiting　directional　adsorption　with　aggregates.　Simultaneously,　weakly　polar　polymer　and　light　components　detach　from　the　aggregate　interface,　vacating　the　active　adsorption　sites　of　aggregates.　Consequently,　ARMs　enhance　the　interaction　at　the　HiMA-aggregate　interface.　Seawater　erosion　induces　water　movement　pathways　at　the　aggregate　interface,　leading　to　the　intrusion　of　ionic　solutions　into　asphalt　molecules　and　the　occupation　of　aggregate　active　sites,　thereby　diminishing　the　direct　interaction　between　polar　asphalt　components　and　aggregate.　The　addition　of　ARMs　reduces　the　deterioration　of　asphalt　nanostructure　at　the　interface　and　the　ion　dissolution　of　asphalt　polar　components　under　seawater　erosion,　thus　improving　the　interaction　at　the　HiMA-aggregate　interface.　Light　shielding　material　exhibits　the　most　effective　enhancement　of　the　asphalt-aggregate　interface　stability　under　seawater　erosion.　©　2024　American　Chemical　Society.