Soil-structure　interaction　(SSI),　which　characterizes　the　dynamic　interaction　between　a　structure　and　its　surrounding　soil,　is　of　great　significance　to　the　seismic　assessment　of　structures.　Past　research　endeavors　have　undertaken　analytical,　numerical,　and　experimental　studies　to　gain　a　thorough　understanding　of　the　influences　of　SSI　on　the　seismic　responses　of　a　wide　array　of　structures,　including　but　not　limited　to　nuclear　power　plants,　frame　structures,　bridges,　and　spatial　structures.　Thereinto,　large-span　spatial　structures　generally　have　much　more　complex　configurations,　and　the　influences　of　SSI　may　be　more　pronounced.　To　this　end,　this　paper　aims　to　provide　a　state-of-the-art　review　of　the　SSI　in　the　seismic　assessment　of　large-span　spatial　structures.　It　begins　with　the　modelling　of　soil　medium,　followed　by　the　research　progress　of　SSI　in　terms　of　numerical　simulations　and　experiments.　Subsequently,　the　focus　shifts　towards　high-lighting　advancements　in　understanding　the　seismic　responses　of　large-span　spatial　structures　considering　SSI.　Finally,　some　discussions　are　made　on　the　unresolved　problems　and　the　possible　topics　for　future　studies.