Although　the　side　chain　ionizability　(the　adsorption　group　density　and　adsorption　space　are　changed)　of　polycarboxylate　superplasticizer　(PCE)　serve　as　the　key　structural　parameter　in　affecting　the　cement　hydration,　its　effect　on　cement　hydration　is　unclear.　Based　on　PCE　with　nonionizable　side　chain　(NSC-PCE)　and　the　PCE　with　ionizable　side　chain　(ISC-PCE),　the　influence　of　the　side　chain　ionizability　of　PCE　on　the　hydration　behavior　of　cement　was　studied.　Compared　with　NSC-PCE,　ISC-PCE　has　a　stronger　ability　to　change　the　migration　of　water　and　ions,　thus　delaying　the　crystal　nucleation　and　growth　of　cement　hydration　(better　morphology　and　distribution,　the　crystal　size　was　reduced　by　more　than　20　%),　increasing　the　crystal　growth　index　(tendency　toward　spherical　growth),　prolonging　the　phase　boundary　reaction　(reduce　micro-cracks),　which　was　conducive　to　the　formation　of　more　uniform　and　dense　crystals　(good　strength,　ISC-PCE:　50.0　MPa　＞　NSC-PCE:　49.2　MPa　＞　Blank:　48.7　MPa).　These　findings　provide　the　design　basis　and　theoretical　guidance　for　the　innovative　development　of　PCE.