In　this　paper,　based　on　the　centrifuge　test　of　liquefied　soil-pile　foundation　system,　a　numerical　model　of　liquefied　soil-pile　foundation-structure　system　is　modelled　by　using　OpenSees　platform.　In　the　simulation　model,　the　friction　effect　between　liquefied　ground　and　low　pile　cap　is　considered,　and　the　method　of　establishing　virtual　nodes　is　used　to　deal　with　the　non-linear　contact　between　liquefiable　soil　and　low　pile　cap.　The　rationality　and　effectiveness　of　the　numerical　simulation　method　adopted　in　this　paper　has　been　verified　and　evaluated　by　comparing　with　the　results　of　centrifuge　experiments.　A　typical　liquefaction　soil-pile　integrated　finite　element　model　is　modelled　using　validated　numerical　simulation　methods.　The　law　of　seismic　response　of　the　pile　foundation　system　with　different　embedding　depths　of　pile　cap,　different　contact　modes　between　the　pile　cap　and　saturated　sand,　and　the　thickness　of　the　overlying　saturated　loose　sand　layer　are　discussed.　The　results　show　that　the　pile　cap　and　pile　foundation　in　the　high　pile　cap　system　show　higher　seismic　response　characteristics　than　the　other　three　low　pile　cap　system　conditions;　Under　the　condition　of　different　contact　modes　between　the　pile　cap　and　the　surrounding　saturated　sand,　the　peak　bending　moment　and　residual　displacement　of　the　pile　foundation　calculated　by　the　bond　contact　are　larger　than　calculated　by　the　friction　contact,　and　the　deformation　of　pile　is　more　significant.　By　comparing　the　working　conditions　of　different　thicknesses　of　overlying　saturated　loose　sand　layer,　it　is　found　that　the　degree　of　liquefaction　in　shallow　soils　is　less　affected　by　thickness　of　the　saturated　loose　sand.　As　the　thickness　of　saturated　loose　sand　layer　increases,　the　peak　bending　moment　and　residual　displacement　at　the　top　of　the　pile　also　gradually　increase.　The　change　of　peak　bending　moment　at　the　soil　interface　is　more　obvious.