Manufactured　sand　(MS)　is　considered　a　reliable　alternative　to　natural　sand　(NS)　in　concrete　due　to　its　wide　availability　and　cost-effectiveness.　In　this　study,　the　influences　of　water-cement　ratio　(0.41,　0.44,　0.47),　replacement　rate　of　MS　(20　%,　60　%,　100　%)　and　stone　powder　content　(0　%,　5　%,　10　%)　on　the　mechanical　and　fracture　characteristics　of　manufactured　sand　concrete　(MSC)　were　investigated.　Statistical　model　of　mechanical　properties　(compressive　strength,　flexural　strength　and　flexural　toughness)　of　MSC　was　constructed　based　on　response　surface　methodology　(RSM).　Acoustic　emission　(AE)　technology　was　used　to　monitor　the　MSC　fracture　process　in　real　time.　The　correlation　between　the　cumulative　AE　parameters　and　the　strength　of　MSC　was　analyzed.　The　results　showed　that　the　compressive　strength,　flexural　strength　and　flexural　toughness　of　MSC　were　negatively　correlated　with　water-cement　ratio　while　positively　correlated　with　the　replacement　rate　of　MS.　The　optimum　stone　powder　content　can　be　determined　for　MSC　to　reach　its　maximum　compressive　strength.　The　coupling　effects　of　water-cement　ratio　and　replacement　rate　of　MS　was　the　most　significant.　This　was　followed　by　the　coupling　effect　of　water-cement　ratio　and　stone　powder　content.　The　coupling　effect　of　stone　powder　content　and　replacement　rate　of　MS　was　the　weakest.　Moreover,　AE　analysis　on　the　fracture　process　of　MSC　indicated　that　the　AE　parameters　were　more　active　when　the　water-cement　ratio　increased.　As　the　replacement　rate　of　MS　increased,　the　AE　parameters　were　smoother　and　the　specimens　were　less　damaged.　The　stone　powder　content　played　greater　role　in　affecting　the　AE　parameters　in　compression,　while　the　effect　of　stone　powder　content　on　the　four-point　bending　test　was　not　significant.　The　cumulative　AE　parameters　were　linearly　related　to　the　strength　of　MSC.　The　cumulative　AE　parameters　can　reflect　the　strength　of　MSC.