Zinc　(Zn)　alloys　have　recently　revolutionized　and　shown　promising　usage　for　degradable　biomedical　implants　(BMI).　However,　due　to　the　low　strength　of　pure　Zn,　its　application　in　the　biomedical　industry　was　limited.　In　the　current　research,　an　innovative　biodegradable　Zn-0.4Li-0.4Cu　alloy　produced　by　laser　powder　bed　fusion　(LPBF)　with　good　mechanical　properties　was　investigated.　The　Zn-0.4Li-0.4Cu　alloy　showed　superior　mechanical　properties　(tensile　strength　at　296　MPa,　yield　strength　at　260　MPa,　and　after　heat　treatment　elongation　at　8.3　%),　a　record　for　biodegradable　Zn　alloys,　as　a　consequence　of　grain　refinement,　second-phase　precipitation　of　intermetallic　compounds,　and　solid　solution　strengthening.　The　impacts　of　Cu　and　Li　on　the　microstructures,　mechanical　behaviors,　corrosive　behavior　and　deterioration　rate　of　the　Zn-0.4Li-0.4Cu　alloy　were　studied.　The　addition　of　Cu　and　inherent　fast-cooling　rate　of　the　LPBF　process　are　favorable　for　promoting　the　nucleation　events,　leading　to　the　refinement　of　grains.　In　addition,　the　formation　of　the　second-phase　precipitates　(CuZn4　and　ZnLi4)　in　the　matrix　was　founded　to　further　improve　the　mechanical　properties.　Moreover,　the　alloy　showed　a　consistent　degradation　manner　and　a　suitable　degradation　rate　of　0.023　mm/year.　Based　on　the　findings　shown　above,　the　biodegradable　Zn-0.4Li-0.4Cu　alloy　can　be　a　potential　candidate　for　vascular　stents　and　medical　applications　due　to　its　excellent　mechanical　properties　and　adequate　degrading　behavior.　©　2024　Elsevier　B.V.