The　overuse　of　antibiotics　poses　a　serious　threat　to　human　health　and　ecosystems.　Therefore,　the　development　of　high-performance　antibiotic　removal　materials　has　attracted　increasing　attention.　However,　the　adsorption　and　removal　of　trace　amounts　of　antibiotics　in　aqueous　systems　still　face　significant　challenges.　Taking　tetracycline　(TC)　as　a　representative　antibiotic　and　based　on　its　structural　characteristics,　a　series　of　TC　adsorbents　are　prepared　by　grafting　alkyl　groups　to　the　framework　of　MIL-101(Cr).　The　adsorptive　capacity　of　the　modified　materials　for　tetracycline　markedly　surpasses　that　of　MIL-101(Cr),　with　MIL-101-dod　achieving　the　best　adsorption　performance.　MIL-101-dod　demonstrated　an　outstanding　ability　to　adsorb　tetracycline　at　low　concentrations,　where　a　5.0　mg　sample　of　MIL-101-dod　can　reduce　the　concentration　of　a　90　mL　5　ppm　tetracycline　solution　to　below　1　ppb,　significantly　superior　to　other　sorbents.　XPS　and　IR　tests　indicate　that　MIL-101-dod　has　multiple　weak　interactions　with　tetracycline　molecules,　including　C　&　horbar;H　&　mldr;O　and　C　&　horbar;H　&　mldr;pi.　This　work　provides　theoretical　and　experimental　support　for　the　development　of　adsorbents　for　low-concentration　antibiotics.　A　series　of　tetracycline　adsorbents　are　prepared　by　grafting　an　alkyl　group　onto　the　MIL-101　skeleton.　Among　these,　MIL-101-dod　has　the　best　adsorption　capacity　for　low-concentration　tetracycline,　with　5.0　mg　of　MIL-101-dod　capable　of　reducing　the　concentration　of　90　mL　5　ppm　tetracycline　solution　to　below　1　ppb.　This　study　provides　theoretical　and　experimental　support　for　the　development　of　low-concentration　antibiotic　adsorbents.　image