Refrigerant　substitution　in　household　air　conditioning　has　become　a　common　concern　in　the　global　refrigeration　and　air　conditioning　industries.　This　study　analyzes　the　specific　clauses　of　the　Kigali　Amendment.　Based　on　the　GWP　value　of　the　R410A　refrigerant,　different　equivalent　factors　were　selected　to　calculate　the　regulatory　limits　of　different　countries　and　regions　in　different　years.　Under　the　restrictions　of　different　national　laws　and　regulations,　three　available　refrigerants　from　R410A,　R32,　R454B,　R161,　and　R290,　have　been　selected　to　represent　different　usage　scenarios.　The　refrigerant　replacement　process　of　HFCs　was　predicted　and　analyzed　following　Kigali′s　revised　Global　Warming　Potential(GWP)　limit,　and　the　influence　of　refrigerant　charge　reduction　was　discussed.　The　results　show　that　to　satisfy　the　Kigali　Amendment,　the　proportion　of　R290　in　Europe　must　exceed　30%　and　become　the　mainstream　refrigerant　in　2024,　whereas　the　United　States　can　realize　the　possibility　of　not　using　R290　by　reducing　the　charge　of　R454B.　China　can　meet　the　GWP　limit　by　using　either　R290　or　R161and　there　is　no　need　to　switch　to　both　two　refrigerants　simultaneously.　©　2024　Journal　of　Refrigeration　Magazines　Agency　Co.,　Ltd..　All　rights　reserved.