When　an　underground　structure　passes　through　a　liquefiable　soil　layer,　the　soil　liquefaction　may　pose　a　significant　threat　to　the　structure.　A　centrifuge　shaking　table　test　was　performed　to　research　the　seismic　response　of　underground　structures　in　liquefiable　interlayer　sites,　and　a　valid　numerical　model　was　obtained　through　simulation　model　test.　Finally,　the　calibrated　numerical　model　was　used　to　perform　further　research　on　the　influence　of　various　distribution　characteristics　of　liquefiable　interlayers　on　the　seismic　reaction　of　underground　structures.　The　key　findings　are　as　follows.　The　structure　faces　the　most　unfavorable　condition　once　a　liquefiable　layer　is　located　in　the　middle　of　the　underground　structure.　When　a　liquefiable　layer　exists　in　the　middle　of　the　structure,　the　seismic　reactions　of　both　the　underground　structure　and　model　site　will　increase　with　the　rise　of　the　thickness　of　the　liquefiable　interlayer.　The　inter-story　drift　of　the　structure　in　the　non-liquefiable　site　is　much　smaller　than　that　in　the　liquefiable　interlayer　site.　The　inter-story　drift　of　the　structure　is　not　only　associated　with　the　site　displacement　and　the　soil-structure　stiffness　ratio　but　also　closely　associated　with　the　slippage　of　the　soil-structure　contact　interface　under　the　condition　of　large　deformation　of　the　site.