The　pharmaceutical　industry　is　a　significant　emission　source　of　water-soluble　volatile　organic　compounds　(VOCs).　However,　these　VOCs　are　primarily　treated　through　adsorption　on　activated　carbon　or　combustion　methods,　leading　to　high　the　generation　of　hazardous　solid　waste　or　energy　consumption.　This　study　proposed　an　innovative　approach　to　address　these　issues　by　integrating　spray　absorption　with　biological　treatment　in　sequencing　batch　reactors　(SBRs).　The　results　indicated　that　after　spray　absorption,　more　than　90　%　of　ethanol　could　be　removed　in　SBRs,　while　1-6　%　of　ethanol　was　emitted　into　the　atmosphere,　depending　on　aeration　intensity　and　ethanol　concentration.　Although　the　intermittent　emissions　of　ethanol　gas　resulted　in　a　high　variation　in　loading　into　the　activated　sludge　system,　stable　and　efficient　treatment　of　ethanol　was　achieved.　Amaricoccus　was　predominated　as　the　primary　bacterium　responsible　for　ethanol　degradation,　indicating　a　robust　microbial　community　capable　of　adapting　to　fluctuating　ethanol　levels.　This　study　provides　an　environment-friendly　and　efficient　solution　to　treating　water-soluble　VOCs.　The　proposed　method　utilizes　existing　infrastructure　such　as　spray　towers　and　biological　treatment　facilities　commonly　found　in　pharmaceutical　enterprises,　making　it　a　cost-effective　and　easily　implementable　technology.　This　study　contributes　to　the　advancement　of　understanding　in　the　field　of　VOCs　treatment.