Air-supported　membrane　structures,　lauded　for　their　flexibility　and　ease　of　construction,　find　increasing　applications　in　large-span　projects.　However,　their　susceptibility　to　wind-induced　damage,　particularly　under　gusty　conditions,　necessitates　advanced　analysis　techniques　to　ensure　structural　integrity.　This　paper　introduces　a　bidirectional　coupled　fluid-structure　interaction　(FSI)　method　for　large-span　air-supported　membrane　structures,　integrating　a　cable　net　and　surrounding　fluid　domain.　The　method　employs　a　two-way　FSI　coupling　scheme,　utilizing　large　eddy　simulation　for　fluid　dynamics　and　membrane-wire　models　for　the　solid　structure,　enhancing　both　accuracy　and　computational　efficiency.　A　geometric　model　of　an　air-supported　membrane　coal　shed　was　developed,　and　its　dynamic　response　under　typhoon　conditions　was　simulated.　In　situ　measurement　data,　including　displacement,　pressure,　and　cable　strain,　recorded　during　a　typhoon　event,　were　compared　with　numerical　simulation　results　to　validate　the　proposed　FSI　framework.　Key　findings　reveal　significant　vertical　displacement　at　the　middle　top　of　the　structure,　with　obvious　fluctuations　on　windward　and　leeward　sides.　Wind　suction　loads　and　cable　strain　measurements　exhibit　distinct　patterns,　with　the　highest　pressures　and　cable　strains　observed　on　the　windward　side.　This　research　bridges　a　critical　gap　in　applying　FSI　analysis　to　practical　engineering　scenarios,　offering　a　validated　approach　for　designing　and　constructing　large-span　air-supported　membrane　structures　resistant　to　wind-induced　damage.