Efficient　drug　delivery　is　crucial　for　glaucoma　patients.　Flexible　biomedical　devices　that　enable　sustained　ocular　drug　delivery　and　can　regulate　the　drug　release　rate　according　to　physiological　conditions　are　highly　desirable　for　glaucoma　treatments,　addressing　both　low　drug　bioavailability　and　poor　patient　compliance　from　manual　drug　administration,　and　improving　treatment　outcomes.　Inspired　by　the　structure　and　reciprocating　motion　of　fish　dorsal　fins,　a　drug-eluting　contact　lens　based　on　deformable　microstructures　for　non-invasive　ocular　surface　drug　delivery　is　developed.　Liquid　drugs　are　stored　within　the　interstices　of　the　deformable　microstructural　units,　allowing　for　continuous　drug　release　through　diffusion　upon　contact　with　the　ocular　surface.　Finite　element　analysis　is　utilized　to　study　the　intraocular　drug　transport　dynamics　of　glaucoma　and　optimize　the　overall　layout　of　the　device.　Microstructural　units　undergo　deformation　under　loading,　altering　the　interstitial　spaces　and　modulating　the　drug　release　rate.　This　device　can　adaptively　adjust　its　drug　release　rate　based　on　changes　in　intraocular　pressure　(IOP)　and　can　be　proactively　regulated　in　response　to　cyclic　eye　loads,　accommodating　elevated　IOP　caused　by　varying　body　postures　and　activities.　As　a　flexible,　non-invasive,　highly　dynamic,　and　adaptive　drug　delivery　platform,　it　holds　significant　potential　for　future　biomedical　applications.