In　this　study,　a　fragility　analysis　of　masonry　structures　is　conducted　using　a　random　sequential　ground　motion　model.　Initially,　the　relationship　between　a　mainshock　and　its　aftershocks　is　clarified　based　on　the　physical　mechanism　of　＂source-path-local　site＂.　Building　on　this,　the　random　sequential　ground　motion　model　is　developed　by　integrating　a　point-source　model　with　a　homogeneous　isotropic　medium　model.　A　five-story　masonry　structure　model　is　then　constructed　in　ABAQUS　(6.14),　and　its　accuracy　is　validated　through　experimental　testing.　Following　this,　21　sets　of　random　sequential　ground　motions　are　generated.　Using　the　Incremental　Dynamic　Analysis　(IDA)　method,　1260　nonlinear　response　samples　of　the　structure　under　varying　sequential　ground　motions　are　obtained,　providing　an　insight　into　the　fragility　of　the　masonry　structure　subjected　to　these　ground　motions.