To　accurately　calculate　the　life　of　rotate　vector　(RV)　reducer　under　actual　operation　and　reduce　the　cycle　and　cost　of　durability　life　test，taking　RV　reducer　for　industrial　manipulator　as　research　object.　A　fatigue　life　calculation　method　of　RV　reducer　based　on　fatigue　strength　theory　was　presented，and　a　device　was　designed　and　built　for　accelerated　life　test.　Combined　with　stress-fatigue　life　(S-N)　curve　and　Palmgren-Miner　rule，the　basic　life　model　of　RV　reducer　was　established.　The　mathematical　expression　of　the　RV　reducer’s　rated　life　and　service　life　was　constructed，the　law　between　the　load　and　service　life　of　the　RV　reducer　was　systematically　studied，and　the　accelerated　life　test　based　on　the　S　curve　acceleration　and　deceleration　control　algorithm　was　designed.　The　test　device　was　set　up　and　the　data　were　analyzed　to　verify　the　accuracy　of　the　life　calculation　method.　The　results　showed　that　the　relative　error　between　the　life　obtained　by　the　fatigue　life　calculation　method　and　the　test　results　was　only　6.3%，the　acceleration　factor　was　20.7，and　the　test　cycle　and　cost　reduction　effect　were　remarkable.　©　2024　Beijing　University　of　Aeronautics　and　Astronautics　(BUAA).　All　rights　reserved.