Permafrost　regions　of　Qilian　Mountains　in　China　are　rich　in　gas　hydrate　resources.　Once　greenhouse　gases　in　deep　frozen　layer　are　released　into　the　atmosphere　during　hydrate　mining,　a　series　of　negative　consequences　occur.　This　study　aims　to　evaluate　the　impact　of　hydrate　thermal　exploitation　on　regional　permafrost　and　carbon　budgets　based　on　a　multi-physical　field　coupling　simulation.　The　results　indicate　that　the　permeability　of　the　frozen　soil　is　anisotropic,　and　the　low　permeability　frozen　layer　can　seal　the　methane　gas　in　the　natural　state.　Heat　injection　mining　of　hydrates　causes　the　continuous　melting　of　permafrost　and　the　escape　of　methane　gas,　which　transforms　the　regional　permafrost　from　a　carbon　sink　to　a　carbon　source.　A　higher　injection　temperature　concentrates　the　heat　and　causes　uneven　melting　of　the　upper　frozen　layer,　which　provides　a　dominant　channel　for　methane　gas　and　results　in　increased　methane　emissions.　However,　dense　heat　injection　wells　cause　more　uniform　melting　of　the　lower　permafrost　layer,　and　the　melting　zone　does　not　extend　to　the　upper　low　permeability　formation,　which　cannot　provide　advantageous　channels　for　methane　gas.　Therefore,　a　reasonable　and　dense　number　of　heat　injection　wells　can　reduce　the　risk　of　greenhouse　gas　emissions　during　hydrate　exploitation.