• Complex
  • Title
  • Keyword
  • Abstract
  • Scholars
  • Journal
  • ISSN
  • Conference
搜索

Author:

Cao, Xin (Cao, Xin.) | Li, Jinghua (Li, Jinghua.) | Zhai, Weijie (Zhai, Weijie.) | Zhou, Bowen (Zhou, Bowen.) | Lin, Hao (Lin, Hao.) | Wang, Yi (Wang, Yi.)

Indexed by:

EI Scopus SCIE

Abstract:

Friction is the trigger cause for excessive exogenous adhesion, leading to the poor self-repair of the tendon. To address this problem, we developed electrospun dual-functional nanofibers with surface robust superlubricated performance and bioactive agent delivery to regulate healing balance by reducing exogenous adhesion and promoting endogenous healing. Coaxial electrospinning and our previous developed in situ robust nanocoating growth techniques were employed to create the lubricative/repairable core-shell structured nanofibrous membrane (L/R-NM). The L/R-NM shell featured a robust coating of the zwitterionic PMPC polymer for strong hydration lubrication to resist exogenous healing. The core could achieve sustained platelet-rich plasma release to promote endogenous healing. Friction tests and cell experiments confirmed L/R-NM's prominent lubricating properties and antiadhesive performance in vitro. Rat tendon injury model evaluation indicated that L/R-NM effectively promotes high-quality tendon repair by inhibiting friction-induced exogenous adhesion and promoting endogenous healing. Therefore, we believe that L/R-NM will open a unique novel horizon for tendon repair.

Keyword:

Author Community:

  • [ 1 ] [Cao, Xin]Hebei Univ, Hebei Int Joint Res Ctr Digital Twin Diag & Treatm, Dept Hepatobiliary Surg, Baoding Key Lab Precis Diag & Treatment Digest Tra, Baoding 071000, Peoples R China
  • [ 2 ] [Li, Jinghua]Hebei Univ, Hebei Int Joint Res Ctr Digital Twin Diag & Treatm, Dept Hepatobiliary Surg, Baoding Key Lab Precis Diag & Treatment Digest Tra, Baoding 071000, Peoples R China
  • [ 3 ] [Zhai, Weijie]Hebei Univ, Hebei Int Joint Res Ctr Digital Twin Diag & Treatm, Dept Hepatobiliary Surg, Baoding Key Lab Precis Diag & Treatment Digest Tra, Baoding 071000, Peoples R China
  • [ 4 ] [Zhou, Bowen]Hebei Univ, Hebei Int Joint Res Ctr Digital Twin Diag & Treatm, Dept Hepatobiliary Surg, Baoding Key Lab Precis Diag & Treatment Digest Tra, Baoding 071000, Peoples R China
  • [ 5 ] [Wang, Yi]Hebei Univ, Hebei Int Joint Res Ctr Digital Twin Diag & Treatm, Dept Hepatobiliary Surg, Baoding Key Lab Precis Diag & Treatment Digest Tra, Baoding 071000, Peoples R China
  • [ 6 ] [Lin, Hao]Beijing Univ Technol, Dept Mech Engn, Beijing 100124, Peoples R China
  • [ 7 ] [Wang, Yi]Beijing Univ Technol, Dept Mech Engn, Beijing 100124, Peoples R China

Reprint Author's Address:

  • [Wang, Yi]Hebei Univ, Hebei Int Joint Res Ctr Digital Twin Diag & Treatm, Dept Hepatobiliary Surg, Baoding Key Lab Precis Diag & Treatment Digest Tra, Baoding 071000, Peoples R China;;[Wang, Yi]Beijing Univ Technol, Dept Mech Engn, Beijing 100124, Peoples R China

Show more details

Related Keywords:

Related Article:

Source :

BIOMACROMOLECULES

ISSN: 1525-7797

Year: 2025

Issue: 2

Volume: 26

Page: 1350-1361

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count:

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 2

Affiliated Colleges:

Online/Total:442/10617095
Address:BJUT Library(100 Pingleyuan,Chaoyang District,Beijing 100124, China Post Code:100124) Contact Us:010-67392185
Copyright:BJUT Library Technical Support:Beijing Aegean Software Co., Ltd.