The　COVID-19　pandemic　has　ushered　in　unprecedented　challenges　globally,　significantly　impacting　mental　health　and　wellbeing.　This　study　examines　the　impact　of　social　disconnectedness　on　mental　health,　when　it　is　imposed　as　forced　action　to　control　the　spread　of　COVID-19.　Moreover,　the　impact　of　family　support　and　religious　commitment　as　key　factors　of　subcontinent　culture　are　analyzed　in　moderating　variables　on　psychological　distress　due　to　social　disconnectedness.　The　data　was　collected　from　450　participants　from　Pakistan　through　a　web-based　survey　using　pre-validated　scales　and　analyzed　using　structure　equation　modelling　(SEM).　The　results　of　the　study　indicate　that　social　disconnectedness　significantly　influences　psychological　distress.　Moreover,　family　support　and　religious　commitment　significantly　moderate　the　relationship　between　social　disconnectedness　and　psychological　distress.　The　social　disconnectedness　strategy　adopted　during　the　COVID-19　outbreak　resulted　in　a　psychological　crisis.　Such　intervention　in　countries　with　weak　economies　and　health　systems　may　result　in　another　pandemic　of　mental　stress.　The　study　highlights　the　critical　need　for　policymakers　to　integrate　culturally　relevant　support　mechanisms,　such　as　family　and　faith-based　interventions　when　designing　public　health　strategies.　Incorporating　such　approaches　can　mitigate　the　mental　health　repercussions　of　future　crises,　ensuring　holistic　community　wellbeing　while　combating　pandemics.