Here,　we　report　carbon-supported　Ni-nanoparticles　as　reusable　catalysts　for　reductive　amidation　of　nitro　compounds　with　polylactic　acid　(PLA).　These　Ni-nanoparticle-based　catalysts　are　prepared　by　synthesizing　nickel-diamine　ligands　on　a　carbon　support　and　subsequent　pyrolysis　under　argon.　Applying　an　optimal　Ni-nanostructured　catalyst,　amidation　of　PLA　with　different　nitro　compounds　in　the　presence　of　molecular　hydrogen　was　performed　to　access　amide　products.　Regarding　improving　the　reaction　efficiency,　H2O　plays　a　positive　role　in　the　PLA　hydrolysis　process　for　lactic　acid　monomer　production.　Meanwhile,　D2O　cannot　promote　PLA　hydrolysis　due　to　the　lack　of　H　atoms,　which　is　vital　for　forming　lactic　acid　monomers.