With　the　rapid　advancement　of　2D　material-based　optoelectronic　devices,　significant　progress　is　made　in　the　development　of　all-optical　logic　devices,　synaptic　biomimetic　devices,　and　multidimensional　detection　systems.　As　entering　to　the　high-speed　information　era,　there　is　an　urgent　demand　for　complex,　compact,　multifunctional,　low-energy,　and　high-speed　intelligent　sensing　chips.　Examining　the　evolution　of　current　technologies　reveals　a　parallel　in　the　advancement　of　bipolar　response　mechanisms-from　simple　positive　and　negative　responses　to　more　intricate　inhibition-promotion　dynamics　with　persistent　characteristics.　This　evolution　significantly　broadens　their　applications　in　biomimetic　devices.　Moreover,　compared　to　unipolar　responses,　complex　bipolar　responses　offer　greater　flexibility　in　adaptation　and　a　unique　one-to-one　mapping　with　high-dimensional　information　parameters　such　as　polarization,　phase,　and　spectrum,　positioning　them　as　promising　candidates　for　breakthroughs　in　multidimensional　detection　and　resolution.　In　this　review,　design　strategies　are　comprehensively　explored　for　various　bipolar　responses　in　2D　materials,　highlighting　their　deep　applications　and　progress　in　advanced　fields.　It　is　aimed　for　this　review　to　provide　a　broad　overview　of　bi-directional　response　mechanisms,　offering　inspiration　for　designing　the　next　generation　of　intelligent　sensing　chips.