In　the　rapidly　expanding　realm　of　the　Industrial　Internet　of　Things　(IIoT),　safeguarding　sensitive　data　against　sophisticated　cyber　threats　has　become　critical.　The　complexity　of　traditional　cryptographic　solutions　often　exceeds　the　limited　computational　capabilities　of　IIoT　devices.　To　address　this,　we　propose　the　Robust　5G　Authentication　Framework　for　Industrial　IoT　(RAFII-RDP),　a　framework　engineered　to　withstand　the　unique　challenges　posed　by　desynchronization　attacks　in　industrial　contexts.　Distinguishing　itself　from　contemporary　lightweight　cryptographic　approaches,　RAFII-RDP　integrates　a　secure　hash　function　with　XOR　encryption　to　significantly　reduce　cryptographic　burdens,　making　it　apt　for　devices　with　limited　resources.　Central　to　our　scheme　is　the　utilization　of　Physical　Unclonable　Functions　(PUFs)　to　generate　distinctive,　device-specific　signatures　that　bolster　data　security　while　obviating　the　need　for　centralized　verification　systems.　Comparative　analysis　reveals　that　RAFII-RDP　achieves　a　34%　reduction　in　memory　usage　for　sensors　and　a　27%　reduction　for　routers　when　measured　against　the　Esfahani　protocol.　Beyond　its　resilience　to　state　misalignments,　our　protocol　enhances　user　privacy　and　data　integrity,　propelling　us　toward　a　more　secure　and　robust　IIoT　infrastructure.　©　The　Author(s),　under　exclusive　license　to　Springer　Nature　Switzerland　AG　2025.