Metal–organic　frameworks　(MOFs)　have　been　at　the　forefront　of　nanotechnology　due　to　their　unique　structural　and　functional　properties.　Herein,　a　pH-responsive　bimetallic　dual-pesticide　nanocomposite　based　on　a　zeolitic　imidazolate　framework　(ZIF)　and　RNA　interference　technology　was　constructed　for　synergistic　control　of　grey　mold.　The　Zn/Co　ZIF　nanocarrier　was　prepared　by　competitive　coordination　of　Zn2+　and　Co2+　with　2-methylimidazole.　The　chemical　fungicide　fluazinam　(Flu)　and　a　biological　pesticide　siRNA　were　simultaneously　encapsulated　into　nanoparticles　(NPs).　The　NPs　had　a　rhombic　dodecahedral　structure　and　a　hydrated　particle　size　of　806.9　±　21.3　nm.　The　loading　rate　of　Flu　was　36.12　%,　and　it　achieved　an　excellent　acid-responsive　release,　with　a　cumulative　release　of　89.6　%　at　72　h.　The　NPs　demonstrated　good　adhesion　properties　and　were　adsorbed　and　translocated　in　pathogenic　fungi　and　crops,　thus　providing　high　efficacy　of　the　non-systemic　fungicides.　Due　to　the　protection　from　the　nanocarriers,　the　stability　of　Flu　and　siRNA　in　the　nanoparticles　significantly　improved　compared　to　a　commercial　formulation.　The　fungicidal　activity　of　the　NPs　on　Botrytis　cinerea　(B.　cinerea)　was　concentration-dependent　and　showed　good　synergistic　effects　due　to　different　mechanisms　of　action　of　the　chemical　and　biological　pesticides　of　the　NPs.　The　NPs　promoted　crop　growth　by　providing　trace　bimetallic　elements　and　exhibited　excellent　biosafety.　This　study　provides　an　upgrade　from　the　traditional　pesticides　in　agricultural　production　and　is　of　great　significance　for　the　sustainable　development　of　agriculture.　©　2025　Elsevier　Ltd