Global　warming　has　significantly　intensified　the　severity　and　frequency　of　dry-wet　(DW)　cycles,　particularly　in　fragile　ecological　regions　such　as　the　Qinghai-Tibet　Plateau,　profoundly　impacting　soil　structure　and　permeability.　However,　the　report　on　the　micro-scale　pore　structure　and　permeability　of　red　clay　in　the　Qinghai-Tibet　Plateau　is　rare.　In　response,　this　study　employs　an　innovative　experimental　technique　to　replicate　the　DW　cycle　of　soil,　combining　with　the　micro-CT　technology　and　permeability　simulations,　to　evaluate　the　impact　of　DW　cycles　on　the　microstructure　and　permeability　of　red　clay.　The　findings　reveal　that　following　a　rising　count　of　DW　cycles,　connected　pore　volume　within　the　soil　sample　rapidly　expands,　while　isolated　pore　volume　initially　decreases　and　then　remains　constant,　highlighting　the　alterations　in　pore　structure　during　the　DW　cycles.　Following　a　rising　count　of　DW　cycles,　connected　porosity　rises　from　4.86　%　to　16.06　%.　This　suggests　that　the　increase　in　DW　cycles　results　in　the　collapse　of　small　pores　and　their　merging　into　large　pores.　Permeability　increases　from　19.72　x　10-6　D　to　250.76　x　10-6　D,　exhibiting　a　trend　of　rapid　growth　followed　by　slow　growth.　Both　the　quantity　and　distribution　density　of　visible　flow　lines　progressively　increase　as　the　DW　cycle　number　increases.