Although　natural　ventilation　can　effectively　control　the　indoor　air　quality　and　thermal　comfort,　the　single-sided　natural　ventilation　in　isolation　hotels　may　lead　to　the　transmission　of　virus-laden　aerosols　between　windows　on　the　same　fa　&　ccedil;ade　but　on　different　floors　near　the　pollution　source.　Hereinafter,　this　kind　of　transmission　is　referred　to　as　inter-flat　transmission.　The　configuration　of　the　building　fa　&　ccedil;ade　is　a　key　factor　influencing　this　risk.　This　study　took　into　account　various　fa　&　ccedil;ade　attachment　scenarios　including　flat　fa　&　ccedil;ades　(with　no　attachments),　outdoor　units　only,　awnings　only,　and　a　combination　of　outdoor　units　and　awnings.　A　model　based　on　a　real　isolation　hotel　was　developed,　and　computational　fluid　dynamics　(CFD)　simulations　were　carried　out　to　investigate　the　inter-flat　transmission　of　aerosols　under　these　fa　&　ccedil;ade　conditions.　The　study　analyzed　the　risk　of　gaseous　pollutant　transmission　caused　by　single-sided　natural　ventilation　and　quantified　the　effects　of　different　outdoor　wind　speeds　and　indoor-outdoor　temperature　differences　on　this　transmission　route.　When　the　indoor-outdoor　temperature　difference　was　5　degrees　C,　the　mass　fraction　of　gaseous　pollutants　in　the　receptor　rooms　above　the　source　first　increased　and　then　decreased　as　the　outdoor　wind　speed　increased,　reaching　a　peak　at　1　m/s.　When　the　outdoor　wind　speed　was　2　m/s,　the　mass　fraction　of　pollutants　in　the　receptor　rooms　increased　with　the　increase　in　the　indoor-outdoor　temperature　difference.　Compared　with　the　flat　fa　&　ccedil;ade,　the　presence　of　outdoor　units　reduced　the　air　exchange　rate　of　natural　ventilation,　resulting　in　a　slight　increase　in　the　infection　risk.　A　1　m-long　awning　reduced　the　infection　risk　associated　with　inter-flat　transmission　by　46%.　Buildings　equipped　with　both　a　1　m-long　awning　and　outdoor　units　achieved　a　68%　reduction　in　infection　risk.　These　findings　provide　valuable　insights　for　mitigating　inter-flat　transmission　and　inform　the　development　of　relevant　policies.