The　efficient　desalination　of　antibiotics　can　be　achieved　by　reasonably　designing　and　enlarging　the　interlayer　channels　of　graphene　oxide　(GO)　membranes.　A　promising　approach　to　increase　the　size　of　these　interlayer　channels　involves　the　incorporation　of　nanoparticles.　However,　challenges　such　as　particle　agglomeration　and　the　formation　of　interfacial　defects　during　the　membrane　fabrication　process　often　hinder　the　efficiency　of　antibiotic　rejection.　To　address　these　issues,　this　study　developed　a　novel　PPD　(Polyp-phenylenediamine)　/GO　nano-hybrid　nanofiltration　membrane　via　in-situ　polymerization.　This　method　ensures　the　uniform　distribution　of　nanoparticles　within　the　interlayer　channels　while　simultaneously　enhancing　membrane　stability　through　covalent　bonding　between　the　nanoparticles　and　GO.　As　a　result　of　the　expanded　mass　transfer　channels,　the　optimized　PPD@GO　membrane　exhibits　a　flux　that　is　3.4-fold　higher　than　that　of　the　pure　GO　membrane,　maintaining　a　high　antibiotic　rejection　rate　and　excellent　sodium　chloride　permeability.　These　findings　demonstrate　the　superior　performance　of　the　PPD@GO　membrane　for　antibiotic　desalination　applications.